Challenge 9

Early Detection and Treatment Of Sepsis

Sepsis occurs when the body reacts to an infection and releases chemicals that cause inflammation as well as organ failure. Early detection of sepsis, with the timely administration of appropriate fluids and antibiotics, appear to be the single most important factors in reducing morbidity and mortality from sepsis. It has become increasingly apparent that there is a long delay in both the recognition of sepsis and the initiation of appropriate therapy in many patients. This translates into an increased incidence of progressive organ failure and a higher mortality. Healthcare providers, therefore, need to have a high index of suspicion for the presence of sepsis and must begin appropriate interventions quickly.

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Sub-Challenges

Statistics

Sepsis was the most expensive condition treated in U.S. hospitals, costing more than $20 billion in 2011.1
1.

Torio, C. M., & Andrews, R. M. (2013). National inpatient hospital costs: the most expensive conditions by payer, 2011.

Sepsis is the number one cause of death in the ICU in the U.S.2
2.

Mayr, F. B., Yende, S., & Angus, D. C. (2014). Epidemiology of severe sepsis. Virulence5(1), 4–11. http://doi.org/10.4161/viru.27372

Sepsis mortality rate is 30-40%.3
3.

Fleischmann, C., Thomas–Rueddel, D. O., Hartmann, M., Hartog, C. S., Welte, T., Heublein, S., … Reinhart, K. (2016). Hospital Incidence and Mortality Rates of Sepsis: An Analysis of Hospital Episode (DRG) Statistics in Germany From 2007 to 2013. Deutsches Ärzteblatt International113(10), 159–166. http://doi.org/10.3238/arztebl.2016.0159

The Agency for Healthcare Research and Quality lists sepsis as the most expensive condition treated in U.S. hospitals, costing more than $20 billion in 2011.4
4.

Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project Statistical Brief No. 160 August 2013. National inpatient hospital costs: the most expensive conditions by payer, 2011.

Severe sepsis is a growing problem in the United States with estimates of up to 3,000,000 hospitalizations per year.4
At least 10 to 15% of sepsis deaths are avoidable by vaccination, hygienic measures, early detection, and prompt treatment measures.5
5.

World Sepsis Day PRNewswire. http://www.world-sepsis-day.org. September 11, 2014.

Severe sepsis and septic shock are major healthcare problems, affecting millions of people around the world each year, killing one in four and often more, and increasing in incidence.6
6.

AMN Healthcare Education Services. (2014). Management of Sepsis in the Adult. Retrieved from: https://lms.rn.com/getpdf.php/2057.pdf