Actionable Patient Safety Solutions (APSS)

Clostridium difficile infection (CDI)
22F Clostridioides difficile Infection

The Clostridioides difficile Infection APSS Blueprint outlines actionable steps healthcare organizations should take to successfully implement and sustain improvements in order to reduce Clostridioides difficile related morbidity and mortality. Actionable steps to improve Clostridioides difficile infection rates and summaries of available evidence-based practice protocols are included:

  • Leadership checklist guide to determine whether current evidence-based guidelines are being followed in your organization
  • Performance improvement plan to follow if improvements are necessary
  • Clinical workflow for Clostridioides difficile prevention and recognition across the continuum
  • Knowledge base on early detection and treatment of Clostridioides difficile infection
  • How to educate patients and family members about Clostridioides difficile prevention, recognition, and treatment
  • Clostridioides difficile infection resource guide
  • Guidance on how to measure outcomes

The Blueprint is revised annually and is available free of charge on our website.

Hospitals who make a formal commitment to improve Clostridioides difficile infection rates and share their successes on the PSMF website have access to an additional level of consulting services.

Executive summary

The Problem Annually, Clostridioides difficile infection (CDI) impacts an estimated 500,000 Americans with approximately 29,000 associated deaths (Mada et al., 2019). Globally, its incidence rate hovers around 2.24 per 1000 admissions annually (Balsells, et al., 2018). CDIs could be entirely eliminated with protocols already available and affordable in healthcare settings, including

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